Labels:text | screenshot | black | font | black and white | document OCR: on of Isolation and chemical ident hypothalamic factors with ar focused on itially, the factors pituitary-regulating propertie fter the first extracts of hypothalamic tissu were known as 'releasing fact n-releasing factor description in 1955 of cortico in-releasing ng factor' was (CRF), now known as cortico hormone (CRH). The term 'r o describe a 1 lobe, which introduced by Saffran and Sch cticotrophic substance extracted from the stimulated the release of adre agments hormone (ACTH) from pitu ty-six years later, maintained in organ culture ce was elucidated the chemical nature of this s by Vale and colleagues (1981)